Joanne Lynette(the nasty first citizen from Fallout 2's vault city), Jacoren (the cunt overseer from Fallout 1), Colin Moriarty, Metzger, Gizmo, Mr. Bishop, Greasy Johnny, Lt Haggerty, Arthur Maxson, and Clandon who works with the Omertas.

@princevegeta2005 wrote:

i really hate that annoying wacky nuka cola addicted girl, also fuuuuuuck the guy who wins the lottery

I think it's safe to say everyone kills him, he didn't win much besides 5 more minutes to live until a Courier on a warpath meets him.

Do mods count? I thought I hated almost every single F3 and F4 character, but oh boy, they seem like F1 characters compared to the ones found in frontier, like america. I cannot name a single well written character from that mod from what I have seen so far, everyone is either a donut steel, a rip off of some other character from another franchise or just flat out badly written or shallow and unimportant. The only guy who got more than a passing glance from me was that legion boss guy you get to kill when you are rescuing the courier, and only because of the stellar voice work from whoever did his lines. And also because he sets himself on fire, that got a chuckle out of me

Colonel Cassandra Moore. Do I need to explain why?

I'd definitely have to go with Ulysses. He's a huge asshole, he steals ede, and he causes the every problem in every DLC, whether directly or indirectly.