I think to remove, clear folders and install FNV again.
And i think i need some help for what mods to install.
What i think to add  is:

NVEC+NVSE - use this as, while old, there is a tons of very nice mods integrated.
EDIT - i read, that this one has a lot of problems. So looks like i need entire mod list..........
Project Nevada
WMX
AWOP
NMC
NVAC

Now, question is - what from all patches to install, and what else i have to install for performance and stability, before i start to add quests, weapons, armors etc.??
If there us a treat about this i fail to find.....

Hello!
I suggest looking in to this ultimate list: https://docs.google.com/document/d/1Zu1FrG9PhMGZAsG5Nslh13sqLOwsBJo4wdaD5YHXD7k/edit
This is really good to get all what is needed for stability etc.
Atleast I have found it useful when reinstalling NV from ground up.

Hey!

I can understand the need to purge and start a new. Of course the headache that follows trying to fully mod out your New Vegas game haha.

That google doc Lekirjaak posted is perfect to help. Just so you know from personal experience over several times of purging and installing, NVSE, NVEC, 4Gig patch, JIP LN NVSE Plugin, MCM, UIO, are a MUST. Because somewhere down the line one or all your mods will need one of these, getting it out of the way first makes it a hell of a lot easier to manage.

Also, a mod on the Nexus called Zan Auto Purge Crash Protector actually helped me a lot. It may help you as well. Also might i recommend any mod that just removes minor assets you probably wouldn't miss anyway, like small rocks, little bits of paper on the ground etc, one called Performance of the Gods by Tommy is a good example. Hope this helps a bit and happy modding!

Also this may be personal preference, but Fallout Quick Loot Menus is almost a must. It just removed a minor headache second of going into an entirely different menu to look say 1 bullet...

Still reading list and description on files from list. And compare to what i have atm.
So i should keep NVEC, and use only YUP?
And yes Quick loot save my day as i have something unusual - when open chest/container/body for looting , or start trade i have about 10-40 sec delay. Sometimes more.

i will keep my current mods at FOMM list - that will make new add way more easy:)