Vortex isn't even playing in the same league as MO2, so the issue is definitely something else.
Can I see an actual loadorder? Because if the loadorder matches the install order I'm seeing in the pic it's definitely not sorted. For starters, the MCM Bugfix is literally flagged as redundant, which means that it's most likely overwritten by the mod it's supposed to fix. And if the DLCs are loaded in the order they are installed, that's also not how it's supposed to be.

Plus, the game really needs the LAA patch, especially with large texture mods. Even if the GOG version is used, which already is LAA patched, running the patcher so NVSE can detect the changes is pretty much mandatory.
And finally, any INI tweaks need to be done with the MO2 ini editor so the Profile inis get edited and not the ones the game generates.
In short, a full list of installed mods plus the actual loadorder will help a lot in troubleshooting the issue.