I'm half-way through a new FO4 playthrough, and I decided to install some extra mods (I have around 90 activated in total atm), however, when I went in game I noticed that they weren't taking effect. I hopped on Vortex (my mod manager) and made sure that mods & plugins were both activated - which they were:

(just an example - this is the Dauntless submarine playerhome plugin)

I spent around 30 minutes last night trying to figure out what was wrong, until I took a look at LOOT. All of the ESPs that I had downloaded yesterday were not seen as activated on LOOT, but on Vortex they were:

(I included 'Improved BOS' just as an example of what an activated plugin should look like)

I have tried reinstalling the mods, both manually and automatically, but nothing's working. There's 5 plugins in total that aren't working, and I installed 4 of them on Friday 14th December, and one of them on Wednesday 12th December.

Edit:
I found a fix, turned out I had to activate all of the ESPs on Nexus Mod Manager as well! I've never had to do that before