So it's not unusual that I'll have a ton of mods in New Vegas, and something from the vanilla game won't work right. It won't be clear why it's not working right since I don't have any mods that affect it. The general attitude and advice in a case like that is to slowly remove and test one mod at a time. But now that the mod limit is gone, my mod limit is just too big to remove one at a time, reloading after each one. Not to mention that removing some mods can cause all kinds of additional problems apparently.
I can't help but think there has to be a better way to find out which mod is busting some aspect of the vanilla game that it shouldn't be touching at all.
A big one is that the silver rush execution doesn't happen when I'm using mods, but when I drop all the mods, it works -- but I sure as hell don't want to tediously drop one mod at a time until I figure out the culprit. That could take a long, long time.

first solution you should take is to carefully read all the descriptions of the mods to download. Second, you have to understand that we can't always use all the mods at once, they will sometimes conflict and you have to accept that. third, download mods that you will actually use, many people download that weapon that they don’t even use in the game, so that mod only serves to spend even more, overload your memory and break the game. also keep in mind that bethesda has a problem with auto save, when you die, the game executes the auosave and many times from then on your game will cause a lot of problems. always load your last save via the menu.

Of course I read the descriptions and know mods can conflict, that's my whole point. I've got a conflict or a bug and I don't know how to figure out which one is causing it.
When you all hit a bug, do you really truly just disable one mod at a time until you find the culprit? Is that really what everyone does? That's...oh my god so horrifyingly tedious.
I'm glad this didn't happen in fallout 4 or skyrim, where I'm often running 300+ mods. I've only got around 150. I really, really hope I don't have to take a day and disable them one at a time.