Recently i stopped playing Fallout 4 for a few weeks, however when i got back to continue were i left off i got this.

http://images.akamai.steamusercontent.com/ugc/172666882850488990/EDE811C831D25CD50788310BE2B6F5CE5B813871/

Be sure to check if everything is ticked, first of all, you should try reinstalling your game, then if nothing happens, you should download any mod manager and tick the files you need.

Or you could also check the Fallout4_Default.ini

Look for [Archive]

It should look like this

[Archive]
sResourceIndexFileList=Fallout4 - Textures1.ba2, Fallout4 - Textures2.ba2, Fallout4 - Textures3.ba2, Fallout4 - Textures4.ba2, Fallout4 - Textures5.ba2, Fallout4 - Textures6.ba2, Fallout4 - Textures7.ba2, Fallout4 - Textures8.ba2, Fallout4 - Textures9.ba2
sResourceStartUpArchiveList=Fallout4 - Startup.ba2, Fallout4 - Shaders.ba2, Fallout4 - Interface.ba2
SResourceArchiveList=Fallout4 - Voices.ba2, Fallout4 - Meshes.ba2, Fallout4 - MeshesExtra.ba2, Fallout4 - Misc.ba2, Fallout4 - Sounds.ba2, Fallout4 - Materials.ba2
SResourceArchiveList2=Fallout4 - Animations.ba2
sResourceDataDirsFinal=STRINGS\
SGeometryPackageList=Fallout4 - Geometry.csg
SCellResourceIndexFileList=Fallout4.cdx
SResourceArchiveMemoryCacheList= Fallout4 - Misc.ba2, Fallout4 - Shaders.ba2, Fallout4 - Interface.ba2, Fallout4 - Materials.ba2

My Ini is exactly as written on the top

@"RikugunTaisaDancho"
Have you checked the contents of file Plugins.txt? And you need to ensure that before the name of each plugin there is a symbol *.

Here is my plugin.txt

https://gyazo.com/672e82e6d9114f92b52dd1c2218314e7

Uh, no idea what's is causing this, but did the game get updated at some point when you were not playing?

Updates might cause incompatibility.

@"RikugunTaisaDancho"
Hmm.. I just did not pay attention. The game complains about the lack of file Fallout.esm! And the DATA directory is present in the game directory? The impression is that it does not exist or the executable can't access it. Maybe try to reinstall the game?

I know what this is cause it's happened to me multiple times, steam cloud synced Fallout 4 and it removes the mods from your data folder, not sure about the base esm's and dlc. But looks like you need to reinstall the game and mods and disable cloud sync.

Ah.... thank you for telling..... Trully a shame.... my current playtrough was the best ouf of any.... oh well...