To check your game file integrity (including installed DLCs) you can go to your steam game list, rightclick Fallout 4 and select properties, then in the properties window go to local files and click "Verify integrity of game cache".
When you say reloading mods what exactly do you mean? Clean saves, redownloading mods,...?
Try disabling your mods see if it still crashes.
_________________
Dota is love, dota is life.