So sometimes when I'm playing, random textures will turn to black. Example. It's really jarring, and the only way I can fix it is to reset archive invalidation, and even then it happens after about 10 or 20 minutes. Anyone know how I can fix it? I play on the lowest vanilla settings, and here's my load order if that helps any.

Maybe you should try starting the game without any mod active, then, slowly, activate them one by one and see if something causes that

I have a similar issue when use SLI settings on my GPUs. If I turn it off, it's fine. Not sure if that helps, but if you're using SLI, I'd suggest turning it off when playing FO4.

Do you have enb? If so try turning it off.