I'm using ttw with fallout nv. I'm used to roaming the wastes in the mojave, but the wasteland in fo 3 seems a little overwhelming. I've already disarmed the bomb in megaton, got a player home, and completed the anchorage dlc.

I'm not too sure what you mean by this? Do you mean what SHOULD you do in FO3? I'd say complete the main story and any side quests you can find, as you'll get the most out of the game, exploration and story wise.

After Anchorage, you're set up with the Winterized T51b PA, so I'd advise you to carry on with the storyline and sidequests up until you get PA Armor training and then complete the rest of the DLCs with the Winterized PA, being it's the strongest Armor in the game it has a long lifespan before it breaks, and by that time, you'd probably have already collected enough caps to repair it.

Complete the sidequests though before you do the other main quests, especially one of them in Megaton (wasteland survival guide) so you get all the benefits out of that before kickstarting into the main story. After that look for more sidequests to gather more caps. The key to Fallout 3 is exploration rather than diving into the main story straight off the bat.

To make the game somewhat easier, play The Pitt after Anchorage, and then Mothership Zeta after Point Lookout. The last DLC, Broken Steel will start itself automatically after the main story so you don't have to worry about visiting a location for it.

Also, like with all the other games, make a build for yourself and stick by your character. I find it way more easy to focus on certain skills than to distribute all my skill points recklessly.

Thanks for the advice! I've just repaired three dog's radio, and I'm about to start the survival guide. I might update this post when I complete the game

Oh yeah, the survival guide is really good, albeit it being a little fetch questy. Hope you enjoy the game!

I'd suggest maybe doing the Those quest since it's not too difficult. I would also say that you may need to head over to Canterbury for the caravans. If you're feeling cocky, try helping out Big Town. Regardless of what you do, I hope you have fun.

Hey man it's your story. Do whatever you want to.

Bad karma, the worst karma, nothing more fun than constantly getting hunted down by regulators and then blowing their brains out for having the audacity to attack you, i mean c'mon

explorer everywhere ,do any and all side quest you find , do the main quest as you go along
when you find Canterbury commons work with the caravans traders

Well, it's totally up to your play style. You can either go for the all-time favourite hero or become the most cunning villain that ever stepped foot on the Capital Wasteland. Perhaps a huge explosion of a certain city will lead you to enlightenment.

Pace yourself. Start doing stuff around Megaton and the surrounding area. I'd suggest Blood Ties, the quest from Lucy West. Branch out at your own speed but try not to get lost. Keep talking to NPCs and you shouldn't miss any big quests.

I recommend Pip-Phone mod for the Wasteland survival quest, so that you don't have to keep traveling back to Moria all the time, however be wary of which NPC you use it with as some NPCs require you be with them first. Rule of thumb don't use it on main story NPCs just sidequests/generic NPCs.

Pip-Phone 3000 by tostikaas
http://www.nexusmods.com/newvegas/mods/55678/?

Try to be a good one, destroy Paradise Folls after getting Clover as your companion.
And for a last walkthrough - complete Mothership Zeta and save Citadel. But it is your choice and your story.

I personally suggest making it a goal to discover every location in the game. Bethesda packed the Capital Wasteland with a lot of interesting locations. For example, there is an entire town that has been taken over by Deathclaws. The town is really dangerous, so I suggest going in there when you know you're well equipped. I really do suggest going there since it has one of the most unique power armors in the game. That is just scratching the surface. There are unmarked locations like satellite towers, small towns, underground areas, you name it. Bethesda really utilized every piece of land the game had to offer.