I'd say House, and his Vegas.
Let's face it, this guy is easily superior to anyone in the game when it comes to intelligence - he saved Vegas from nuclear annihilation, sustained himself for two centuries in a machine, and managed to build New Vegas into what it is now despite being completely disabled physically.
He restored civilization to Vegas, turned a bunch of raiders and cannibals into entrepreneurs.
With House's intelligence and the Courier's physical prowess and combat capability, they can form a great alliance. House is pretty much essential for the future of mankind.
Remember, this guy has only recently woken up. A few decades of him in full power could turn New Vegas into a new world superpower, and especially a hub of civilization, advancement and knowledge.
_________________A secret message to the chosen ones: