I played GTA V on console .. for about an hour .. and now I have come back to it on my PC and love it. Unlike some previous posters, I have had no technical difficulties with the game (I don't consider a long load time to be a tech difficulty - annoying yes, but .. hey .. I can live with it).
Much has been said so I will not repeat - my favorite things:
The humor: I don't think any game has ever skewered America and American culture so effectively and so deeply. From the radio commercials, the billboards, the random-person-banter, the TV Shows (Fame or Shame had me laughing to tears at one point - as a child of 80s heavy metal, the lyrics to "This is a Power Ballad" just killed me - could not stop laughing. Won't stop me from keeping on as a heavy metal kinda girl, but sooooo damn funny). Also - there were moments were you get to do things you really wish you could in real life but can't (I am thinking of a particular mission involving the LifeInvader founder - being a San Franciscan who has to deal with LifeInvader's real-life counterpart, well, lets just say I was cheering all the way through that mission).
The Visuals: Someone said earlier about the sunsets, but it goes true for the whole day-night cycle (but especially the sunsets). I am a Californian, I live above a beach in San Francisco, and I watch the sunset over the ocean every night - and GTA V's sunsets are the best I've seen in a game and look damn good. This extends on to many other aspects of the game - get up high, like on top of the bridge towers or something, and look around. Its amazing.
Sandy Shores: Ever been to the Salton Sea? 'Nuff said. Brilliant!
TREVOR! Holy shizzle is this guy fun to play. He is a walking, talking, shooting, killing bag of things you are not supposed to do in polite society and doing those things is what GTA V is all about. He is awesome. In real life? Holy hells I'd hope he'd end up dead or in the ADX fast, but to play him in game? SOOOO fun! Makes Michael look like a pus...uh ... you know .. a wimp. And Franklin is just kinda boring in comparison.
Things I hate:
Airplanes. Can't fly 'em to save my life (literally).
Time: Meaning ... this game is sucking up all my free time! I suppose that's arguably a good thing.
Lack of meaningful decisions: FO3/FONV gave us some pretty meaningful decisions to make - you could be good, evil, mercenary, altruistic, and in FONV, you could decide which of 4 factions would prevail. In GTA V, you get to play through the missions and decide how to approach some jobs ("Smart" or "Loud" etc.) but by and large when it comes to actual character development and the central story, you just watch it. You don't really get to decide how Franklin, Michael or Trevor are going to act. Don't get me wrong - the writing is brilliant and the voice acting excellent, but ... you are sort of on rails as far as the story goes.
BIGGEST COMPLAINT: NO FEMALE PROTAGONIST!!!!! WTF?!?!?!? We are on the fifth installment of this franchise and this one has THREE protagonists and they can't make just ONE of them female?!? REALLY? Come on, that SUX. There are gamer girls out there (*points at self*) and we would like a female protagonist once in a while. and with THREE in this game, they could have made at least one of them female. Hmmph. Jerks.
OK, that's it. For the TL;DR crowd, I can sum it up fast: It was fun!